What is a common side effect of metoclopramide used in pregnancy?

Metoclopramide is an antiemetic medication often used to treat nausea and vomiting during pregnancy, particularly in cases of hyperemesis gravidarum. A well-documented side effect of this medication is drowsiness, which occurs because metoclopramide crosses the blood-brain barrier and affects central nervous system function. This drowsiness can be significant enough that it cautions healthcare providers to advise pregnant individuals about avoiding activities that require full alertness, such as driving.

While other side effects can occur with metoclopramide use, such as insomnia, constipation, or headache, they are generally less common compared to drowsiness. The sedative effect is a critical factor for patients and healthcare providers to consider when prescribing this medication during pregnancy, ensuring that the benefits outweigh the risks.